Recombinant factor VIIa and factor VIII treatment for acquired factor VIII deficiency: a case of repeated thrombotic endotracheal occlusion in a mechanically ventilated patient

A is caused by autoantibodies to coagulation factor VIII (FVIII). Preoperative diagnosis is impaired by the lack of a personal or family history of bleeding episodes. Th erefore, surgical procedures can lead to life-threatening hemorrhage [1]. We present a case of a 72-year-old woman who had no history of coagulopathy and who was undergoing hys-tero scopy and abrasion in a district hospital. Persistent vaginal bleeding began immediately after surgery, resulting in vaginal hysterectomy on postoperative day (POD) 7 and multiple re-laparotomies with intermittent abdominal packing between PODs 8 and 37. Acquired FVIII defi ciency was suspected on POD 30, but a disseminated intravascular coagulation and treatment with various pro-coagulants made the defi nitive diagnosis diffi cult. Bolus applications of recombinant factor VIIa (rFVIIa) and von Willebrandt factor-FVIII complex between PODs 33 and 38 plus prednisolone pulse therapy remained ineff ective. Acquired FVIII defi ciency was fi nally diagnosed upon admission of the intubated and ventilated patient to the intensive care unit of a university hospital on POD 40. Further FVIII was administered because of persistent surgical bleeding. Following massive abdominal bleeding on POD 44, the patient received FVIII for the next 24 hours and rFVIIa until POD 49. On POD 47, the abdominal bleeding ceased. Th ree life-threatening airway complications occurred under rFVIIa and FVIII therapy. On POD 40, the endotracheal tube (ETT) was completely obstructed by blood clots. On POD 46, pulmonary gas exchange rapidly deteriorated because of a huge thrombus in the left main bronchus (2 × 5 cm). On POD 49, a large endobronchial thrombus (2 × 7 cm), which was attached to the tip of the ETT, was fortunately extracted during the emergency removal of the ETT (Figure 1a,b). Each time, bronchoscopy showed only moderate diff use bleeding from minor mucosal erosions. After the critical incident on POD 49, the patient was weaned from the respirator and eventually fully recovered. Intravascular thromboembolic events under treatment with rFVIIa and FVIII present a well-known complication [2,3]. Life-threatening thrombotic airway obstructions in a mechanically ventilated patient, however, are a rare complication. Th e fact that activated partial thrombo-plastin times (aPTTs) were spontaneously prolonged (53 to 66 seconds) and active bleeding was present during these events highlights the unpredictable local imbalance of pro-and anticoagulant eff ects during such a treatment. In conclusion, intensive care clinicians should be aware that minor lacerations of the bronchial mucosa in mechanically ventilated patients could …